Potential Cosmeceutical Applications and Evaluation of Human Skin Irritation of Tagetes erecta L. Flower Extract

Pharmacognosy Research,2021,13,4,199-207.DOI:10.5530/pres.13.4.12Published:October 2021Type:Original ArticleAuthors:Catheleeya Mekjaruskul, Supakanya Kumkarnjana, Niramai Fangkrathok, Worapol Kengkittipat, and Nuttawut Sirichat Author(s) affiliations:Catheleeya Mekjaruskul1,*, Kumkarnjana1, Fangkrathok2, Kengkittipat1, Sirichat1 1Faculty of Pharmacy, Mahasarakham University, Kantharawichai, Maha Sarakham, THAILAND. 2Faculty Agricultural Technology, Burapha Sakaeo Campus, Watthana Nakhon, Sa Kaeo, Abstract:Background: Tagetes erecta L. has been traditionally used for treatment skin diseases. Objectives: This study aimed to evaluate in vitro anti-aging, antioxidant, antibacterial activities, human irritation T. flower extract development as a cosmeceutical product using aqueous, 50%, 95% ethanolic extracts flower. Methods: Total phenolic content was defined. Quantitative analysis syringic acid determined by HPLC. Antioxidant activities were performed measurement 2,2-diphenyl 1-pichylhydazyl free radical scavenger. Anti-aging assays monitored inhibitory effects on tyrosinase, elastase, hyaluronidase, collagenase activities. Antibacterial against Staphylococcus aureus epidermidis also investigated. The formulated lotion its stability evaluated tests performed. Results: had significantly higher total than the other extracts. stronger DPPH scavenging elastase hyaluronidase enzyme those 50% or water showed better activity S. epidermidis. developed containing 1% ethanol stable. Moreover, not observed healthy volunteers after applying lotion. Conclusion: indicates that extracts, especially extract, are potential sources products enzymes/reactions responsible aging bacterial infection. Keywords:Anti-aging, Asteraceae, Marigold, Skin irritation, L.View:PDF (1.24 MB)